ZUPLENZ for chemotherapy-induced nausea and vomiting (CINV)


CINV occurs in up to 90% of patients undergoing moderately emetogenic chemotherapy10



In moderately emetogenic chemotherapy1,7



  • 61% of patients receiving moderately emetogenic chemotherapy experienced no emetic episodes during the study period1,7
  • 5-HT3 receptor antagonists are recommended by major guidelines for management of CINV10-13

ASCO | NCCN | MASCC | ASHP


Important Safety Information

  • The most common adverse drug reactions (≥5%) reported in clinical trials of patients receiving ondansetron 8 mg twice daily for prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy compared to placebo were headache (24% vs 13%), malaise/fatigue (13% vs 2%), constipation (9% vs <1%), and diarrhea (6% vs 4%)

ZUPLENZ delivers the trusted efficacy of ondansetron in a quick-dissolving film

  • Packaged for discreet, on-the-go use
  • Can be taken with or without water1
  • Dissolves rapidly in the mouth in about 10 seconds14-16
  • Is nonsedating1
  • Can be taken anytime, anywhere

ASCO=American Society of Clinical Oncology.
NCCN=National Comprehensive Cancer Network.
MASCC=Multinational Association of Supportive Care in Cancer.
ASHP=American Society of Health-System Pharmacists.


*Not an actual patient.



For the prevention of postoperative, highly and moderately emetogenic cancer chemotherapy-induced, and radiotherapy-induced nausea and vomiting.

The concomitant use of apomorphine with ondansetron is contraindicated based on reports of profound hypotension and loss of consciousness when apomorphine was administered with ondansetron.

ZUPLENZ (ondansetron) oral soluble film is contraindicated for patients known to have hypersensitivity to the drug. Anaphylactic reactions have been reported in patients taking ondansetron.

Hypersensitivity reactions, including anaphylaxis and bronchospasm, have been reported in patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists.

Avoid ZUPLENZ in patients with congenital long QT syndrome. Monitor ECG in patients with electrolyte abnormalities (e.g., hypokalemia or hypomagnesemia), congestive heart failure, bradyarrhythmias or patients taking other medicinal products that lead to QT prolongation.

Serotonin syndrome has been reported with 5-HT3 receptor antagonists alone but particularly with concomitant use of serotonergic drugs.

The use of ondansetron in patients following abdominal surgery or in patients with chemotherapy-induced nausea and vomiting may mask a progressive ileus and/or gastric distension.

The most common adverse drug events (≥5%) in chemotherapy-induced nausea and vomiting and radiotherapy-induced nausea and vomiting were: headache, malaise/fatigue, constipation, and diarrhea. The most common adverse event (≥5%) in postoperative nausea and vomiting was headache.

ZUPLENZ is available by prescription only. Please click here for complete Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.FDA.gov/medwatch, or call 1-800-FDA-1088.

For more information about ZUPLENZ, call 1-855-636-5710.