The following section is provided to help you better evaluate the efficacy, safety, and benefits of ZUPLENZ® (ondansetron).
For further details about ZUPLENZ, please see the Complete Prescribing Information.

What are the indications for ZUPLENZ?

ZUPLENZ is indicated for the prevention of highly and moderately emetogenic cancer chemotherapy-induced, radiotherapy-induced, and postoperative nausea and vomiting.

What is the active ingredient in ZUPLENZ?

The active ingredient in ZUPLENZ is ondansetron, which has been shown to be effective in the prevention of nausea and vomiting.

How is ZUPLENZ different from other antiemetics?

ZUPLENZ is the first and only 5-HT3 receptor antagonist available in an oral soluble film that prevents nausea and vomiting. ZUPLENZ films dissolve rapidly in the mouth in about 10 seconds and can be taken with or without water. Each peppermint-flavored film is individually packaged for discreet, on-the-go use.

How does ZUPLENZ compare to ondansetron orally disintegrating tablets?

In 3 clinical studies, under varying conditions, ZUPLENZ was found to be comparable to ondansetron orally disintegrating tablets.

ZUPLENZ delivers the trusted efficacy of ondansetron in a quick-dissolving film. ZUPLENZ dissolves rapidly in the mouth in about
10 seconds and can be taken with or without water. Pleasant peppermint flavor. No gritty aftertaste.

ZUPLENZ can be conveniently dosed up to 3 times per day to manage acute nausea and vomiting episodes.

What is the recommended dosing for ZUPLENZ?

ZUPLENZ is available in 4-mg and 8-mg films, the same strength as oral ondansetron, with the same recommended dosing. Dosing varies according to indication. Please refer to the Complete Prescribing Information for ZUPLENZ.

What are the most common side effects of ZUPLENZ?

The most common side effects of ZUPLENZ are headache, fatigue and body discomfort, constipation, and diarrhea.